{Author}: Lijun Xie, Jie Huang, Jian Zuo, Hui Yu and Yuanrong Cheng*

{Journal}: Acta Crystallographica

{Year}: 2012

{Volume}:68

{Issue}:4

{Pages}: o1206-o1207

{Abstract}:The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide anti­biotic mol­ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy­droxy groups giving an intra­molecular hydrogen bond to a ketone O-atom acceptor. The mol­ecules also form inter­molecular hy­droxy-ketone O-HO hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids.