41-Azido-41-deoxyrapamycin

{Author}: Lijun Xie, Jie Huang, Jian Zuo, Hui Yu and Yuanrong Cheng*

{Journal}: Acta Crystallographica

{Year}: 2012

{Volume}:68

{Issue}:4

{Pages}: o1206-o1207

{Abstract}:The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hydroxy groups giving an intramolecular hydrogen bond to a ketone O-atom acceptor. The molecules also form intermolecular hydroxy-ketone O-HO hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids.

Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors

40-Deoxy-40(S)-iodorapamycin

Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors

40-Deoxy-40(S)-iodorapamycin

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