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Structure elucidation and antitumour activity of a new macrolactam produced by marine-derived actinomycete Micromonospora sp. FIM05328
{Author}: Yi-Lei Nie,Yun-Dan Wu,Chuan-Xi Wang,Ru Lin,Yang Xie,Dong-Sheng Fang,Hong Jiang,Yun-Yang Lian*
{Journal}: Natural product research
{Year}: 2018
{Volume}: 32
{Issue}: 18
{Pages}: 2133-2138
{Keywords}: Micromonospora； antitumour activity； aurodox； macrolactam
{Abstract}: Chemical investigation of a marine-derived actinomycete strain Micromonospora sp. FIM05328 isolated from a soil sample collected from the East China Sea, resulted in the discovery of a new 26-membered polyene macrolactam metabolite FW05328-1 (1), together with a known polyene with pyridone ring compound aurodox (2). The structures of compounds 1 and 2 were determined by the detailed analysis of 1D, 2D NMR and HR-TOF-MS data, along with literature data analysis. 1 and 2 exhibited excellent antiproliferative activities against KYSE30, KYSE180 and EC109 human tumour cell lines, but displayed no antibacterial activities against bacteria or fungi were tested.
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